The effect of resveratrol on toxicity caused by cisplatin in rats with experimentally created diabetes by streptozotocin

Aim: In our study, the therapeutic effect of resveratrol against toxicity cisplatin in rats with experimental diabetes mellitus streptozotocin was investigated.
 Material and Method: 64 were used study. 8 groups randomly formed, each group. Group 1 determined as control 2 (STZ) injected 60 mg/kg intraperitoneally (ip) on first day to induce diabetes. 3 (RES) given 100 orally every day. 4 (SIS), a single dose 7 administered days later. 5 (STZ+RES), group 6 (STZ+SIS), (RES+SIS) (STZ+SIS+RES) determined.
 Results: While there weight gain RES during experiment, STZ + SIS showed significant decrease body weights rats. together resveratrol, no weight, but small increase observed. increased blood glucose values streptozotocin, these found have dropped significantly resveratrol. The TAS level has RES, STZ+RES, SIS+RES STZ+SIS+RES according group; difference been other compared AST higher STZ, STZ+SIS group, ALT be Creatinine SIS, STZ+SIS, RES+SIS compared, statistically significant. QT (ms) groups. According heart rate per minute lower groups.
 Conclusion: As result, it seen that use would effective reducing levels treatment possible complications.